xylitol, 87-99-0 - The Good Scents Company

a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. it is as sweet as sucrose and used as a noncariogenic sweetener. Occurs in a variety of plants, berries and fruits including plums, raspberries, cauliflower and endive; sweetening agent used in sugar free sweets and chewing gum Possessing approximately 40% less food energy, xylitol is a low-calorie alternative to table sugar. Absorbed more slowly than sugar, it does not contribute to high blood sugar levels or the resulting hyperglycemia caused by insufficient insulin response.; Xylitol (from Greek ????? - xyl[on], "wood" + suffix -itol, used to denote sugar alcohols) is an organic compound with the formula (CHOH)3(CH2OH)2. This achiral species is one of four isomers of 1,2,3,4,5-pentapentanol. This sugar alcohol is used as a naturally occurring sugar substitute found in the fibres of many fruits and vegetables, including various berries, corn husks, oats, and mushrooms. It can be extracted from corn fibre, birch, raspberries, plums, and corn. Xylitol is roughly as sweet as sucrose with only two-thirds the food energy. As with most sugar alcohols, consumption can result in bloating, diarrhea, and flatulence, although generally rather less so than other sugar alcohols like sorbitol.; Xylitol is a "tooth friendly" non-fermentable sugar alcohol. A systematic review study on the efficacy of xylitol has indicated dental heath benefits in caries prevention, showing superior performance to other polyols (poly-alcohols). Early studies from Finland in the s found that a group chewing sucrose gum had 2.92 decayed, missing, or filled (dmf) teeth compared to 1.04 in the group chewing xylitol gums. In another study, researchers had mothers chew xylitol gum 3 months after delivery until their children were 2 years old. The researchers found that children in the xylitol group had "a 70% reduction in cavities (dmf)." Recent research confirms a plaque-reducing effect and suggests that the compound, having some chemical properties similar to sucrose, attracts and then "starves" harmful micro-organisms, allowing the mouth to remineralise damaged teeth with less interruption. (However, this same effect also interferes with yeast micro-organisms and others, so xylitol is inappropriate for making yeast-based bread, for instance.); Xylitol is a five-carbon sugar alcohol. Xylitol is in a natural state in many fruits (strawberries, plums, raspberries) and vegetables (cauliflower...). The human body naturally processes 15gram xylitol per day during digestion. It can be produced industrially starting from primary matters rich in xylan which is hydrolized to obtain xylose. It is extracted from hemicelluloses present in the corn raids, the almond hulls or the barks of birch (or of the by-products of wood: shavings hard, paper pulp). Of all polyols, it is the one that has the sweetest flavor (it borders that of saccharose). It gives a strong refreshing impression, while remaining not cariogene; as a result, chewing xylitol gum may prevent dental caries. Chewing xylitol gum for 4 to 14 days reduces the amount of plaque. The reduction in the amount of plaque following xylitol gum chewing within 2 weeks may be a transient phenomenon. Chewing xylitol gum for 6 months reduced mutans streptococci levels in saliva and plaque in adults. (PMID: , ); these three qualities make xylitol an ingredient of choice for the industry of chewing gums without sugar. In addition to his use in confectionery, one finds it in pharmaceutical industry, certain baths of mouth and toothpastes, in cosmetic (creams, soaps...). Xylitol is produced starting from xylose, the isomaltose, by enzymatic transposition of the saccharose (sugar). Xylitol is not metabolized by cariogenic bacteria and gum chewing stimulates the flow of saliva D-Arabitol is a polyol. Polyols are sugar alcohols linked to the pentose phosphate pathway (PPP). They are classified on the basis of the number of carbon atoms. Polyols occur in body fluids. A patient with leukoencephalopathy and peripheral neuropathy has been identified as suffering from ribose-5-phosphate isomerase (RPI) deficiency, a defect in the PPP. In this disorder, highly elevated concentrations of the C5 polyols such as D-arabitol are found in body fluids. In addition, transaldolase deficiency, another defect in the PPP, has been diagnosed in a patient with mainly liver problems among others had increased concentrations of polyols, mainly D-arabitol. So far, the pathophysiological role of polyols is relatively unknown. It is thought that D-arabitol is a metabolic end-product in humans. The strong brain-CSF-plasma gradient of polyols in the patient with RPI deficiency suggested a primary metabolic disorder. The mechanisms of brain and neuronal damage in RPI deficiency remain to be elucidated. A neurotoxic effect due to accumulation of the polyols may play a role. D-Arabitol is a product of the enzyme D-arabinitol 4-dehydrogenase (EC 1.1.1.11) in the Pentose and glucuronate interconversion pathway. (PMID: , J Inherit Metab Dis. ;28(6):-3)

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